Deoxyneocryptotanshinone

CAT: 0804-HY-N3734Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-N3734Size:1 Each

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Description

Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].

CAS Number

27468-20-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Beta-secretase; Phosphatase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/deoxyneocryptotanshinone.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C(C)C)=C(O)C(C2=C1C=CC3=C2CCCC3(C)C)=O

Molecular Formula

C19H22O3

Molecular Weight

298.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Ting Yu, et al. Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations. Comput Biol Chem. 2018 Jun;74:273-285. |[2]Da Hye Kim, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Deoxyneocryptotanshinone

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