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Glp-Asn-Pro-AMC

CAT: 0804-HY-P10485-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10485-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a Ki value of 0.97 μM[1].
CAS Number
291752-43-7
UNSPSC
12352209
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glp-asn-pro-amc.html
Purity
99.26
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CC(C1=CC=C(NC([C@H]2N(CCC2)C([C@H](CC(N)=O)NC([C@@H]3CCC(N3)=O)=O)=O)=O)C=C1O4)=CC4=O
Molecular Formula
C24H27N5O7
Molecular Weight
497.50
References & Citations
[1]Charli JL, et al. The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? Front Pharmacol. 2020 May 8;11:640.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Glp-Asn-Pro-AMC
CAS Number291752-43-7
PubChem CID10255308
IUPAC Name(2S)-N-[(2S)-4-amino-1-[(2S)-2-[(4-methyl-2-oxochromen-7-yl)carbamoyl]pyrrolidin-1-yl]-1,4-dioxobutan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular FormulaC24H27N5O7
Molecular Weight497.5
XLogP-1.3
Topological Polar Surface Area177
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity995
SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(=O)N)NC(=O)[C@@H]4CCC(=O)N4
InChI
InChI=1S/C24H27N5O7/c1-12-9-21(32)36-18-10-13(4-5-14(12)18)26-23(34)17-3-2-8-29(17)24(35)16(11-19(25)30)28-22(33)15-6-7-20(31)27-15/h4-5,9-10,15-17H,2-3,6-8,11H2,1H3,(H2,25,30)(H,26,34)(H,27,31)(H,28,33)/t15-,16-,17-/m0/s1
InChIKey
YSNGYDACLOQMCZ-ULQDDVLXSA-N
Chemical Structure
2D Structure
2D structure of Glp-Asn-Pro-AMC
CAS: 291752-43-7
CID: 10255308
Formula: C24H27N5O7
MW: 497.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight497.5
XLogP3-1.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass497.19104822
Monoisotopic Mass497.19104822
Topological Polar Surface Area177 Ų
Heavy Atom Count36
Formal Charge0
Complexity995
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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