Z-Ala-Ala-Asn-AMC

Z-Ala-Ala-Asn-AMC

• CAS Number: 149697-16-5
• UNSPSC Description: Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].
• Target Antigen: Fluorescent Dye
• Type: Peptides
• Related Pathways: Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/z-ala-ala-asn-amc.html
• Smiles: O=C(N)C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](C)NC([C@H](C)NC(OCC3=CC=CC=C3)=O)=O)=O
• Molecular Weight: 565.57
• References & Citations: [1]Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510.|[2]James C. Powers, et al. Propenoyl hydrazides. US7482379B2.|[3]Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035.
• Shipping Conditions: Blue Ice