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Metyrapone (Standard)

CAT: 0804-HY-B1232R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1232R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression[1][2][3][4][5].
CAS Number
54-36-4
Product Name Alternative
Su-4885 (Standard)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Autophagy; Cytochrome P450; Endogenous Metabolite; Reference Standards
Type
Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Endocrinology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metyrapone-standard.html
Purity
90.000000
Smiles
CC(C1=CC=CN=C1)(C)C(C2=CC=CN=C2)=O
Molecular Formula
C14H14N2O
Molecular Weight
226.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Roozendaal B, et al. Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory. Psychoneuroendocrinology. 1996 Nov;21 (8) :681-93.|[2]Jahn H, et al. Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry. 2004 Dec;61 (12) :1235-44.|[3]Daniel E, et al. Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients. J Clin Endocrinol Metab. 2015 Nov;100 (11) :4146-54.|[4]Peterson JA, Ullrich V, Hildebrandt AG. Methyrapone interaction with Pseudomonas putida cytochrome P-405. Arch Biochem Biophys. 1971 Aug;145 (2) :531-42.|[5]Holczer M, et al. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference Standards

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