Products for Research Use Only
RegisterLogin

Metyrapone (Tartrate)

CAT: 0804-HY-B1232ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1232ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression[1][2][3][4][5].
CAS Number
908-35-0
Product Name Alternative
Su-4885 (Tartrate)
UNSPSC
12352005
Target
Autophagy; Cytochrome P450; Endogenous Metabolite; mTOR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/metyrapone-tartrate.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C(C1=CC=CN=C1)=O)C2=CC=CN=C2.O=C([C@@H]([C@H](C(O)=O)O)O)O.O=C([C@@H]([C@H](C(O)=O)O)O)O
Molecular Formula
C22H26N2O13
Molecular Weight
526.45
References & Citations
[1]Roozendaal B, et al. Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory. Psychoneuroendocrinology. 1996 Nov;21 (8) :681-93.|[2]Jahn H, et al. Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry. 2004 Dec;61 (12) :1235-44.|[3]Daniel E, et al. Effectiveness of Metyrapone in Treating Cushing's Syndrome: A Retrospective Multicenter Study in 195 Patients. J Clin Endocrinol Metab. 2015 Nov;100 (11) :4146-54.|[4]Peterson JA, Ullrich V, Hildebrandt AG. Methyrapone interaction with Pseudomonas putida cytochrome P-405. Arch Biochem Biophys. 1971 Aug;145 (2) :531-42.|[5]Holczer M, et al. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName
HY-B1232-01Metyrapone
HY-B1232R-01Metyrapone (Standard)
HY-105182A-01Xanomeline (tartrate)
HY-117985B-01Evogliptin (tartrate)
HY-14834A-01Budiodarone (tartrate)
HY-14829BAfegostat (tartrate)
HY-B0519-01Tylosin (tartrate)
HY-10021-01Varenicline (Tartrate)
HY-139347A-01Mazisotine (tartrate)
HY-129783Phenindamine (tartrate)

Alternative Products

CatalogName
T0293L-01Metyrapone Tartrate
456174-01Metyrapone

Popular Products