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Isophysalin A

CAT: 0804-HY-N11085Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N11085Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1].
CAS Number
1363398-67-7
UNSPSC
12352005
Target
IKK; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isophysalin-a.html
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@@](OC1=O)([H])C2)(OC3=O)[C@]([C@@]3(CC[C@@]([C@]45C)([H])[C@@]6([H])[C@@H](C=C4C=CCC5=O)O)O)(O[C@@]76O)[C@](C7=O)([H])[C@]2(C1=C)C
Molecular Formula
C28H30O10
Molecular Weight
526.53
References & Citations
[1]Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77 (5) :441-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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