Isophysalin A

• Description :

  Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1].

• UNSPSC :

  12352005

• Target :

  IKK; NO Synthase

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/isophysalin-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]([C@@](OC1=O)([H])C2)(OC3=O)[C@]([C@@]3(CC[C@@]([C@]45C)([H])[C@@]6([H])[C@@H](C=C4C=CCC5=O)O)O)(O[C@@]76O)[C@](C7=O)([H])[C@]2(C1=C)C

• Molecular Formula :

  C28H30O10

• Molecular Weight :

  526.53

• References & Citations :

  [1]Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77 (5) :441-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [1363398-67-7]