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Calcium dobesilate

CAT: 0804-HY-111603-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111603-01Size:500 mg
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Description
Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions[1][2][3].
CAS Number
20123-80-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Calcium_dobesilate.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=S(C1=CC(O)=CC=C1O)([O-])=O.O=S(C2=CC(O)=CC=C2O)([O-])=O.[Ca+2]
Molecular Formula
C12H10CaO10S2
Molecular Weight
418.41
Precautions
H315, H319, H335
References & Citations
[1]J Brunet, et al. In vitro antioxidant properties of calcium dobesilate. Fundam Clin Pharmacol. 1998;12 (2) :205-12.|[2]GA Losa, et al. Prevention of Oxidation and Apoptosis in Human Peripheral Blood Mononuclear Cells Exposed to Calcium Dobesilate. Int J Angiol. 1999;8 (5) :11-15.|[3]Patricia Bogdanov, et al. Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice. J Diabetes Complications. 2017 Oct;31 (10) :1481-1490.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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Alternative Products

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C6371-100Calcium dobesilate
269480-01Calcium dobesilate monohydrate
SEA55278-01Calcium Dobesilate Hydrate
RM-D151929-01Calcium dobesilate-D3
RM-D151921-01Calcium Dobesilate Impurity 21
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