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M4K2308

CAT: 0804-HY-167864Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167864Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM) . M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research[1].
CAS Number
3034840-18-8
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m4k2308.html
Smiles
COC(C=C1C2=C3C(C4=CC=C(N5CCNCC5)C=C4OCC3)=CN=C2)=C(C(OC)=C1)OC
Molecular Formula
C26H29N3O4
Molecular Weight
447.53
References & Citations
[1]Héctor González-Álvarez, et al. Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67 (6) :4707-4725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2; ALK5

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