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M4K2306

CAT: 0804-HY-161377Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161377Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6[1].
CAS Number
3034840-25-7
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m4k2306.html
Solubility
10 mM in DMSO
Smiles
CN1CC(C(C2=CC(OC)=C(C(OC)=C2)OC)=CN=C3)=C3C4=CC=C(N5CCN(CC5)C)C=C4C1
Molecular Formula
C28H34N4O3
Molecular Weight
474.59
References & Citations
[1]González-Álvarez H, et al., Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67 (6) :4707-4725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK2; ALK5

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