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Phospho-ASK1 (Thr845) Rabbit Polyclonal Antibody

CAT: 0013-GTR17725181-01Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0013-GTR17725181-01Size:50 μL
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Description
Phospho-ASK1 (Thr845) Rabbit Polyclonal Antibody
Product Name Alternative
ASK1; MAPKKK5; MEKK5; 7420452D20Rik; ASK; M3K5_HUMAN; MAP3K5; Apoptosis signal-regulating kinase 1 (ASK-1) ; MAPK/ERK kinase kinase 5 (MEK kinase 5 | MEKK 5) ; 2.7.11.25; M3K5_MOUSE; mitogen-activated protein kinase kinase kinase 5; apoptosis signal regulating kinase 1; MAP3K5 | ASK1 (phospho-T845) ; p-ASK1; phospho-ASK1; p-MAP3K5; MAP3K5 | ASK1 (phospho-Thr845)
UniProt
Q99683
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated Synthesised phosphopeptide derived from human ASK1 around the phosphorylation site of Thr845 TE (p-T) FT
Target
MAP3K5
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Affinity purified by Protein A
Concentration
1mg/ml
Dilution
WB=1:500-2000, Flow-Cyt=1μg /test
Form
Liquid
Molecular Weight
155 kDa
References & Citations
Chiara Imarisio, Elisa Alchera, Chandrashekar Bangalore Revanna, Guido Valente, Antonia Follenzi, Elena Trisolini, Renzo Boldorini, Rita Carini Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury Free Radical Biology and Medicine, 112, 141 (2017), Jiaxuan He 1 2, Siyuan Li 1, Yunpeng Teng 1, Hongfei Xiong 1, Zhuang Wang 1, Xiaoyao Han 1, Wei Gong 2, Ya Gao Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway Autoimmunity, 57, 2345919 (2024)
Pubmed id
28739531, 38721693
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Prediction Reactivity
Mouse, Rat
Tested Applications
FC, WB
Host or Source
Rabbit
Preservative
0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol.
Isotype
IgG

UniProtKB · Q99683

Mitogen-activated protein kinase kinase kinase 5

M3K5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99683
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
A6NIA0, B4DGB2, Q5THN3, Q99461
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interactionImmunityInnate immunityStress response

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Domain

Coiled coil

Cellular component

CytoplasmEndoplasmic reticulum

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

MethylationPhosphoproteinUbl conjugation

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