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α-Synuclein (67-78) (human)

CAT: 0804-HY-P5043Size: 1 EachDry Ice: NoHazardous: No
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Description
α-Synuclein (67-78) (human) is the 67-78 fragment of α-Synuclein. α-Synuclein (67-78) (human) promotes network activity drive and blocks KCl-induced syt1L-ab uptake[1].
CAS Number
2243206-99-5
UNSPSC
12352209
Target
α-synuclein
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-synuclein-67-78-human.html
Solubility
10 mM in DMSO
Smiles
NCC(NCC(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C43H76N12O15
Molecular Weight
1001.13
References & Citations
[1]Lazarevic V, et al. α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release. NPJ Parkinsons Dis. 2022 Jun 7;8 (1) :71.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
α-synuclein

Chemical Information

alpha-Synuclein (67-78) (human)
CAS Number2243206-99-5
PubChem CID169450554
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]propanoic acid
Molecular FormulaC43H76N12O15
Molecular Weight1001.1
XLogP-4.4
Topological Polar Surface Area424
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count16
Rotatable Bond Count29
Heavy Atom Count70
Formal Charge0
Complexity1880
SMILES
C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)CN)O
InChI
InChI=1S/C43H76N12O15/c1-17(2)29(39(65)55-34(25(13)57)42(68)48-22(10)36(62)51-30(18(3)4)38(64)49-23(11)43(69)70)50-28(60)16-46-37(63)33(24(12)56)54-41(67)32(20(7)8)53-40(66)31(19(5)6)52-35(61)21(9)47-27(59)15-45-26(58)14-44/h17-25,29-34,56-57H,14-16,44H2,1-13H3,(H,45,58)(H,46,63)(H,47,59)(H,48,68)(H,49,64)(H,50,60)(H,51,62)(H,52,61)(H,53,66)(H,54,67)(H,55,65)(H,69,70)/t21-,22-,23-,24+,25+,29-,30-,31-,32-,33-,34-/m0/s1
InChIKey
RLQJFIMZENSKJL-GDDAQVLUSA-N
Chemical Structure
2D Structure
2D structure of alpha-Synuclein (67-78) (human)
CAS: 2243206-99-5
CID: 169450554
Formula: C43H76N12O15
MW: 1001.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1001.1
XLogP3-4.4
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count16
Rotatable Bond Count29
Exact Mass1000.55530976
Monoisotopic Mass1000.55530976
Topological Polar Surface Area424 Ų
Heavy Atom Count70
Formal Charge0
Complexity1880
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
4107368.1000Α-Synuclein (67-78) (human)
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OM301595-01ENA 78 Human (8-78 a.a.)
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RC312-16TENA-78, CXCL5 (8-78 a.a.), human
GTR18984558-01Human ENA 78 (8-78 a.a.) Protein
PT_74261-01Epithelial Neutrophil-Activating Protein 78, 8-78 a.a. Human Recombinant (CXCL5) (ENA 78 Human (8-78 a.a.) )
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