IL-21

• Background:

  IL-21 induces the production of IgG1 and IgG3 in B-cells. IL-21 may promote the transition between innate and adaptive immunity. IL-21 may have a role in proliferation and maturation of natural killer cells in synergy with IL15. IL-21 stimulates interferon gamma production in T-cells and natural killer cells by synergy with IL15 and IL18. Dysregulation of IL-21 has a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases.

• Description:

  Recombinant Human Interleukin-21 is produced by our E.coli expression system and the target gene encoding Gln23-Ser155 is expressed.

• Synonyms:

  Interleukin-21; IL-21; Za11; IL21

• Expression System:

  E. Coli

• Endotoxin:

  Less than 0.1 ng/ µg (1 IEU/ µg) as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE.

• Form:

  Lyophilized

• Shipping Conditions:

  The product is shipped at ambient temperature.

• Formulation:

  Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.2.

• Species:

  Human

• Shipping Temperature:

  Ambient