IGF1

• Background:

  Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.

• Description:

  Recombinant Human Insulin-like Growth Factor I (4-70) is produced by our E.coli expression system and the target gene encoding Thr52-Ala118 is expressed.

• Synonyms:

  Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; mgF; Somatomedin-C; IGF1; IBP1

• Expression System:

  E. Coli

• Endotoxin:

  Less than 0.05 ng/ µg (0.5 IEU/ µg) as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE.

• Form:

  Lyophilized

• Shipping Conditions:

  The product is shipped at ambient temperature.

• Formulation:

  Lyophilized from a 0.2 μm filtered solution of 300mM NaAc, pH 6.5.

• Species:

  Human

• Shipping Temperature:

  Ambient