IL-6

• Background :

  Cytokines of the IL6/GCSF/ mgF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

• Description :

  Recombinant Human Interleukin-6 is produced by our E.coli expression system and the target gene encoding Pro29-Met212 is expressed.

• Synonyms :

  Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2

• Expression System :

  E. Coli

• Endotoxin :

  Less than 0.1 ng/ µg (1 IEU/ µg) as determined by LAL test.

• Purity :

  Greater than 90% as determined by reducing SDS-PAGE.

• Form :

  Lyophilized

• Shipping Conditions :

  The product is shipped at ambient temperature.

• Formulation :

  Lyophilized from a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 5.0.

• Species :

  Human

• Shipping Temperature :

  Ambient