IL-1F1/IL-1a

• Background:

  Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.

• Description:

  Recombinant Human Interleukin-1 alpha is produced by our E.coli expression system and the target gene encoding Ser113-Ala271 is expressed.

• Synonyms:

  Interleukin-1 Alpha; IL-1 Alpha; Hematopoietin-1; IL1A; IL1F1

• Expression System:

  E. Coli

• Endotoxin:

  Less than 0.1 ng/ µg (1 IEU/ µg) as determined by LAL test.

• Purity:

  Greater than 95% as determined by reducing SDS-PAGE.

• Form:

  Lyophilized

• Shipping Conditions:

  The product is shipped at ambient temperature.

• Formulation:

  Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.

• Species:

  Human

• Shipping Temperature:

  Ambient