CD206 antibody

• Background :

  CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia.

• Synonyms :

  Macrophage mannose receptor 1 (MMR) |C-type lectin domain family 13 member D|C-type lectin domain family 13 member D-like|Human mannose receptor (hMR) |Macrophage mannose receptor 1-like protein 1|MRC1|CLEC13D|CLEC13DL|MRC1L1

• Gene ID :

  4360

• UniProt :

  P22897

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Mannose receptor, C type 1

• Target :

  CD206

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IF

• Field of Research :

  Neuroscience, Immunology

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  166 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IF

• Immunogen Sequence :

  19-148aa