CD209 antibody

CAT: 0710-FNab01443Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01443Size:100 µg
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Background
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2 (PubMed:11799126, PubMed:12502850, PubMed:1518869) . Acts as an attachment receptor for ebolavirus (PubMed:12502850, PubMed:12504546) . Acts as an attachment receptor for cytomegalovirus (PubMed:12433371, PubMed:22496863) . Acts as an attachment receptor for HCV (PubMed:15371595, PubMed:16816373) . Acts as an attachment receptor for dengue virus (PubMed:12682107) . Acts as an attachment receptor for measles virus (PubMed:16537615) . Acts as an attachment receptor for herpes simplex virus 1 (PubMed:18796707) . Acts as an attachment receptor for Influenzavirus A (PubMed:21191006) . Acts as an attachment receptor for SARS coronavirus (PubMed:15140961) . Acts as an attachment receptor for Japanese encephalitis virus (PubMed:24623090) . Acts as an attachment receptor for Lassa virus (PubMed:23966408) . Acts as an attachment receptor for marburg virusn (PubMed:15479853) . Acts as an attachment receptor for Respiratory syncytial virus (PubMed:22090124) . Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus (PubMed:21767814) . Acts as an attachment receptor for west-nile virus (PubMed:16415006) . Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA (PubMed:16379498) . Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule (PubMed:16092920, PubMed:21203928) .
Synonyms
CD209 antigen|C-type lectin domain family 4 member L|Dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN, DC-SIGN1) |CD209|CLEC4L
Gene ID
30835
UniProt
Q9NNX6
Host
Rabbit
Reactivity
Human
Immunogen
CD209 molecule
Target
CD209
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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