TLR4 antibody

• Background :

  TLR4, also named as CD284, belongs to the Toll-like receptor family. TLR4 cooperates with LY96 and CD14 to mediates the innate immune response to bacterial lipopolysaccharide (LPS) . TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

• Synonyms :

  Toll-like receptor 4|hToll|TLR4

• Gene ID :

  7099

• UniProt :

  O00206

• Host :

  Mouse

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Toll-like receptor 4

• Target :

  TLR4

• Clonality :

  Monoclonal

• Isotype :

  IgG2b

• Applications :

  ELISA, WB, IHC

• Field of Research :

  Neuroscience, Immunology, Signal Transduction, Developmental biology

• Purification :

  Protein A+G purification

• Dilution :

  WB: 1:1000-1:8000; IHC: 1:50-1:500

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  100 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID :

  3E7

• Tested Applications :

  ELISA, WB, IHC

• Immunogen Sequence :

  650-839aa