ZRANB3 antibody

CAT: 0710-FNab09756Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab09756Size:100 µg

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Background

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Synonyms

DNA annealing helicase and endonuclease ZRANB3|Annealing helicase 2 (AH2) |Zinc finger Ran-binding domain-containing protein 3|ZRANB3

Gene ID

84083

UniProt

Q5FWF4

Host

Rabbit

Reactivity

Human

Immunogen

Zinc finger, RAN-binding domain containing 3

Target

ZRANB3

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:200-1:2000; IF: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

150 kDa and 50 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB

UniProtKB · Q5FWF4

DNA annealing helicase and endonuclease ZRANB3

ZRAB3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q5FWF4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ZRANB3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B3KYA1, B4E375, B5MDI3, D3DP76, E9PBP0, Q53SM1, Q6P2C4, Q8N1P4, Q9H0E8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Cellular component

ChromosomeNucleus

Biological process

DNA damageDNA repair

Molecular function

EndonucleaseHelicaseHydrolaseIsomeraseMultifunctional enzymeNuclease

PTM

MethylationPhosphoprotein

Domain

Zinc-finger

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