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XRCC5 antibody

CAT: 0710-FNab09555Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09555Size:100 µg
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Background
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Synonyms
X-ray repair cross-complementing protein 5|86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit (CTC85, CTCBF) |DNA repair protein XRCC5|Ku80|Ku86|Lupus Ku autoantigen protein p86|Nuclear factor IV|Thyroid-lupus autoantigen (TLAA) |X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |XRCC5|G22P2
Gene ID
7520
UniProt
P13010
Host
Rabbit
Reactivity
Human
Immunogen
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Target
XRCC5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
83kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · P13010

DNA repair protein Ku80

XRCC5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P13010
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
XRCC5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
4.2.99.18, 5.6.2.4
Processing
—
Secondary accessions
A8K3X5, Q0Z7V0, Q4VBQ5, Q53HH7, Q7M4N0, Q9UCQ0, Q9UCQ1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingHelicaseHydrolaseIsomeraseLyase

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Biological process

DNA damageDNA recombinationDNA repairHost-virus interactionImmunityInnate immunityRibosome biogenesisTranscriptionTranscription regulation

Disease

Systemic lupus erythematosus

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