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XRCC4 antibody

CAT: 0710-FNab09554Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09554Size:100 µg
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Background
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V (D) J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED) . Alternative splicing generates several transcript variants.
Synonyms
DNA repair protein XRCC4 (hXRCC4) |X-ray repair cross-complementing protein 4|Protein XRCC4, C-terminus (XRCC4/C) |XRCC4
Gene ID
7518
UniProt
Q13426
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
X-ray repair complementing defective repair in Chinese hamster cells 4
Target
XRCC4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · Q13426

DNA repair protein XRCC4

XRCC4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13426
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
XRCC4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hXRCC4
EC number
—
Processing
—
Secondary accessions
A8K3X4, Q9BS72, Q9UP94
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeCytoplasmNucleus

Domain

Coiled coil

Disease

Disease variantDwarfism

Biological process

DNA damageDNA recombinationDNA repair

Molecular function

DNA-binding

PTM

Isopeptide bondPhosphoproteinUbl conjugation

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