WRAP53 antibody

• Background :

  Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs) . The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

• Synonyms :

  Telomerase Cajal body protein 1|WD repeat-containing protein 79|WD40 repeat-containing protein antisense to TP53 gene (WRAP53beta) |WRAP53|TCAB1|WDR79

• Gene ID :

  55135

• UniProt :

  Q9BUR4

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  WD repeat containing, antisense to TP53

• Target :

  WRAP53

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IP

• Field of Research :

  Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:1000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  72 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IP