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WDFY3 antibody

CAT: 0710-FNab09479Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09479Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures) . May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
Synonyms
WD repeat and FYVE domain-containing protein 3|Autophagy-linked FYVE protein (Alfy) |WDFY3|KIAA0993
Gene ID
23001
UniProt
Q8IZQ1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
WD repeat and FYVE domain containing 3
Target
WDFY3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC

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