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VEGFA antibody

CAT: 0710-FNab09391Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09391Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) . VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189 (38kd), VEFGA110 (34kd) . VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010) .
Synonyms
Vascular endothelial growth factor A, long form (L-VEGF) |Vascular permeability factor (VPF) |N-VEGF|VEGFA|VEGFA|VEGF
Gene ID
7422
UniProt
P15692
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Vascular endothelial growth factor A
Target
VEGFA
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB
Field of Research
Signal Transduction, Cardiovascular, Cancer, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
15-27 kDa, 34-45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB
Immunogen Sequence
27-232aa

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