Phospho-VEGF Receptor 2 (Y1175) antibody

• Background:

  KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

• Synonyms:

  Vascular endothelial growth factor receptor 2 (VEGFR-2) |Fetal liver kinase 1 (FLK-1) |Kinase insert domain receptor (KDR) |Protein-tyrosine kinase receptor flk-1|KDR|FLK1|VEGFR2

• Gene ID:

  3791

• UniProt:

  P35968

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2

• Target:

  Phospho-VEGF Receptor 2 (Y1175)

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  250 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC