VAMP8 antibody

• Background:

  SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604) . Also required for dense-granule secretion in platelets (PubMed:12130530) . Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity) . Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity) . Involved in the homotypic fusion of early and late endosomes (By similarity) .

• Synonyms:

  Vesicle-associated membrane protein 8 (VAMP-8) |Endobrevin (EDB) |VAMP8

• Gene ID:

  8673

• UniProt:

  Q9BV40

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Vesicle-associated membrane protein 8 (endobrevin)

• Target:

  VAMP8

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  15 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB

• Immunogen Sequence:

  1-75aa