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UPF3A antibody

CAT: 0710-FNab09271Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09271Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Synonyms
Regulator of nonsense transcripts 3A|Nonsense mRNA reducing factor 3A|Up-frameshift suppressor 3 homolog A (hUpf3) |UPF3A|RENT3A|UPF3
Gene ID
65110
UniProt
Q9H1J1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
UPF3 regulator of nonsense transcripts homolog A (yeast)
Target
UPF3A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC:1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
51 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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