ULK1 antibody

• Background :

  ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200) (PMID:21460634) . ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC (PMID:23573318) .

• Synonyms :

  Serine/threonine-protein kinase ULK1|Autophagy-related protein 1 homolog (ATG1, hATG1) |Unc-51-like kinase 1|ULK1|KIAA0722

• Gene ID :

  8408

• UniProt :

  O75385

• Host :

  Rabbit

• Reactivity :

  Human, Rat

• Immunogen :

  Unc-51-like kinase 1 (C. elegans)

• Target :

  ULK1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB,IHC

• Field of Research :

  Cardiovascular, Metabolism, Developmental biology, Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:200-1:1000; IHC: 1:50-1:500

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  150 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC

• Immunogen Sequence :

  Peptide, aa400-aa500