ULK1 antibody

• Background:

  ULK1, also named as KIAA0722, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and APG1/unc-51/ULK1 subfamily. It is involved in autophagy. ULK1 is required for autophagosome formation. It forms a stable complex with Atg13 and focal adhesion kinase (FAK) family interacting protein of 200 kDa (FIP 200) (PMID:21460634) . ULK1 phosphorylates ATG13/KIAA0652. It is involved in axon growth. ULK1 plays an essential role in neurite extension of cerebellar granule cells. ULK1 represents a potential novel prognostic biomarker for HCC patients and may play an important role during the progression of HCC (PMID:23573318) .

• Synonyms:

  Serine/threonine-protein kinase ULK1|Autophagy-related protein 1 homolog (ATG1, hATG1) |Unc-51-like kinase 1|ULK1|KIAA0722

• Gene ID:

  8408

• UniProt:

  O75385

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  Unc-51-like kinase 1 (C. elegans)

• Target:

  ULK1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB,IHC

• Field of Research:

  Cardiovascular, Metabolism, Developmental biology, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000; IHC: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  150 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  Peptide, aa400-aa500