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UIMC1 antibody

CAT: 0710-FNab09247Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab09247Size:100 µg
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Background
Ubiquitin-binding protein (PubMed:24627472) . Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36) . Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Synonyms
BRCA1-A complex subunit RAP80|Receptor-associated protein 80|Retinoid X receptor-interacting protein 110|Ubiquitin interaction motif-containing protein 1|UIMC1|RAP80|RXRIP110
Gene ID
51720
UniProt
Q96RL1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Ubiquitin interaction motif containing 1
Target
UIMC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC,IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
97 kDa, 80 kDa, 71-75 kDa, 61 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC, IF

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