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UBE3A antibody

CAT: 0710-FNab09189Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09189Size:100 µg
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Background
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Synonyms
Ubiquitin-protein ligase E3A|E6AP ubiquitin-protein ligase|HECT-type ubiquitin transferase E3A|Human papillomavirus E6-associated protein|Oncogenic protein-associated protein E6-AP|Renal carcinoma antigen NY-REN-54|UBE3A|E6AP|EPVE6AP|HPVE6A
Gene ID
7337
UniProt
Q05086
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ubiquitin protein ligase E3A
Target
UBE3A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

UniProtKB · Q05086

Ubiquitin-protein ligase E3A

UBE3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q05086
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UBE3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.26
Processing
—
Secondary accessions
A8K8Z9, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsHost-virus interactionUbl conjugation pathway

Cellular component

CytoplasmNucleusProteasome

Disease

Disease variant

Ligand

Metal-bindingZinc

PTM

Phosphoprotein

Molecular function

Transferase

Domain

Zinc-finger

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