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UBE2K antibody

CAT: 0710-FNab09178Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab09178Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Synonyms
Ubiquitin-conjugating enzyme E2 K|E2 ubiquitin-conjugating enzyme K|Huntingtin-interacting protein 2 (HIP-2) |Ubiquitin carrier protein|Ubiquitin-conjugating enzyme E2-25 kDa (Ubiquitin-conjugating enzyme E2 (25K), Ubiquitin-conjugating enzyme E2-25K) |Ubiquitin-protein ligase|UBE2K|HIP2|LIG
Gene ID
3093
UniProt
P61086
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ubiquitin-conjugating enzyme E2K
Target
UBE2K
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Immunology, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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