TRPC4AP antibody

• Background:

  Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX (TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1.

• Synonyms:

  Short transient receptor potential channel 4-associated protein (Trp4-associated protein, Trpc4-associated protein) |Protein TAP1|TNF-receptor ubiquitous scaffolding/signaling protein (Protein TRUSS) |TRPC4AP|C20orf188|TRRP4AP

• Gene ID:

  26133

• UniProt:

  Q8TEL6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Transient receptor potential cation channel, subfamily C, member 4 associated protein

• Target:

  TRPC4AP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IP, IHC, WB

• Field of Research:

  Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  91 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IP, IHC, WB