TRIM21 antibody

• Background:

  This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

• Synonyms:

  E3 ubiquitin-protein ligase TRIM21|52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|RING finger protein 81|Ro (SS-A) |Sjoegren syndrome type A antigen (SS-A) |Tripartite motif-containing protein 21|TRIM21|RNF81|RO52|SSA1

• Gene ID:

  6737

• UniProt:

  P19474

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Tripartite motif-containing 21

• Target:

  TRIM21

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Epigenetics, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  54 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF

• Immunogen Sequence:

  76-326aa