TRIAP1 antibody

• Background :

  Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759) . Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602) . Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003) .

• Synonyms :

  TP53-regulated inhibitor of apoptosis 1|Protein 15E1.1|WF-1|p53-inducible cell-survival factor (p53CSV) |TRIAP1|15E1.1

• Gene ID :

  51499

• UniProt :

  O43715

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  TP53 regulated inhibitor of apoptosis 1

• Target :

  TRIAP1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB

• Field of Research :

  Cell Division and Proliferation

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:5000

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  32 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB