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TNPO2 antibody

CAT: 0710-FNab08844Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08844Size:100 µg
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Background
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) .
Synonyms
Transportin-2|Karyopherin beta-2b|TNPO2
Gene ID
30000
UniProt
O14787
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Transportin 2
Target
TNPO2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90-100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF

UniProtKB · O14787

Transportin-2

TNPO2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14787
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNPO2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O14655, Q6IN77
Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Disease variantIntellectual disability

Biological process

Protein transportTransport

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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