TMPRSS2 antibody

• Background:

  This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Synonyms:

  Transmembrane protease serine 2|Serine protease 10|Transmembrane protease serine 2 non-catalytic chain|Transmembrane protease serine 2 catalytic chain|TMPRSS2|PRSS10

• Gene ID:

  7113

• UniProt:

  O15393

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Transmembrane protease, serine 2

• Target:

  TMPRSS2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  52 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC

• Immunogen Sequence:

  110-360aa, extra-cellular domain