TLE1 antibody

• Background:

  Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

• Synonyms:

  Transducin-like enhancer protein 1|E (Sp1) homolog|Enhancer of split groucho-like protein 1 (ESG1) |TLE1

• Gene ID:

  7088

• UniProt:

  Q04724

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Transducin-like enhancer of split 1 (E (sp1) homolog, Drosophila)

• Target:

  TLE1

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Signal Transduction, Metabolism, Cancer, Immunology, Developmental biology

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  85 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  8F4

• Tested Applications:

  ELISA, WB, IHC