TIMM8A antibody

CAT: 0710-FNab08703Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08703Size:100 µg
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Background
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
Synonyms
Mitochondrial import inner membrane translocase subunit Tim8 A|Deafness dystonia protein 1|X-linked deafness dystonia protein|TIMM8A|DDP|DDP1|TIM8A
Gene ID
1678
UniProt
O60220
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Translocase of inner mitochondrial membrane 8 homolog A (yeast)
Target
TIMM8A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
11 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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