TBC1D5 antibody

CAT: 0710-FNab08515Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab08515Size:100 µg
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Background
May act as a GTPase-activating protein (GAP) for Rab family protein (s) . May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837) . Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) ; the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992) . May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492) .
Synonyms
TBC1 domain family member 5|TBC1D5|KIAA0210
Gene ID
9779
UniProt
Q92609
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TBC1 domain family, member 5
Target
TBC1D5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2400; IP: 1:200-1:1000 ; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
89 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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