TBC1D17 antibody

• Background :

  Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC) . Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.

• Synonyms :

  TBC1 domain family member 17|TBC1D17

• Gene ID :

  79735

• UniProt :

  Q9HA65

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  TBC1 domain family, member 17

• Target :

  TBC1D17

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IF, IHC

• Field of Research :

  Signal Transduction

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  73-100 kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IF, IHC

• Immunogen Sequence :

  1-350aa