SUPV3L1 antibody

CAT: 0710-FNab08397Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab08397Size:100 µg

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Background

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Synonyms

ATP-dependent RNA helicase SUPV3L1, mitochondrial|Suppressor of var1 3-like protein 1 (SUV3-like protein 1) |SUPV3L1|SUV3

UniProt

Q8IYB8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Suppressor of var1, 3-like 1

Target

SUPV3L1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IP, WB

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

70-80 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IP, WB

UniProtKB · Q8IYB8

ATP-dependent RNA helicase SUPV3L1, mitochondrial

SUV3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q8IYB8
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: SUPV3L1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.6.4.13
Processing: Precursor
Secondary accessions: A8K301, O43630

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Molecular function

HelicaseHydrolase

Cellular component

MitochondrionMitochondrion nucleoidNucleus

Domain

Transit peptide

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Alternative Products

Catalog	Name
MBS7134147-01	SUPV3L1 Antibody
STJ111992	Anti-SUPV3L1 antibody
RD85430A-01	SUPV3L1 Polyclonal Antibody
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