STAM2 antibody

• Background:

  Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex) . The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity) .

• Synonyms:

  Signal transducing adapter molecule 2 (STAM-2) |Hrs-binding protein|STAM2|HBP

• Gene ID:

  10254

• UniProt:

  O75886

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

• Target:

  STAM2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP

• Field of Research:

  Epigenetics, Signal Transduction

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:200-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  68 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP