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SSX2IP antibody

CAT: 0710-FNab08258Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08258Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) . May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity) . Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity) . Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777) . Involved in ciliogenesis (PubMed:24356449) . It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449) .
Synonyms
Afadin- and alpha-actinin-binding protein (ADIP) |Afadin DIL domain-interacting protein|SSX2-interacting protein|SSX2IP|KIAA0923
Gene ID
117178
UniProt
Q9Y2D8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synovial sarcoma, X breakpoint 2 interacting protein
Target
SSX2IP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
64 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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