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SQLE antibody

CAT: 0710-FNab08209Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08209Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting) . It is also posttranslationally regulated by cholesterol-dependent proteasomal degradation. (PMID:21356516) The MW of SQLE is about 64kd.
Synonyms
Squalene monooxygenase|Squalene epoxidase (SE) |SQLE|ERG1
Gene ID
6713
UniProt
Q14534
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Squalene epoxidase
Target
SQLE
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
64 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, IF

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