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SNRPB antibody

CAT: 0710-FNab08070Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08070Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.
Synonyms
Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) |Sm protein B/B' (Sm-B/B', SmB/B') |SNRPB|COD|SNRPB1
Gene ID
6628
UniProt
P14678
Host
Rabbit
Reactivity
Human
Immunogen
Small nuclear ribonucleoprotein polypeptides B and B1
Target
SNRPB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
25-30 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
A synthetic peptide (1-100AA)

UniProtKB · P14678

Small nuclear ribonucleoprotein-associated proteins B and B'

RSMB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14678
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNRPB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
snRNP-B
EC number
—
Processing
—
Secondary accessions
Q15490, Q6IB35, Q9UIS5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleusSpliceosome

Disease

Disease variantIntellectual disability

PTM

Methylation

Biological process

mRNA processingmRNA splicing

Domain

Repeat

Molecular function

RibonucleoproteinRNA-binding

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