SNAPIN antibody

• Background:

  Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355) . As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167) .

• Synonyms:

  SNARE-associated protein Snapin|Biogenesis of lysosome-related organelles complex 1 subunit 7 (BLOC-1 subunit 7) |Synaptosomal-associated protein 25-binding protein (SNAP-associated protein) |SNAPIN|BLOC1S7|SNAP25BP|SNAPAP

• Gene ID:

  23557

• UniProt:

  O95295

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  SNAP-associated protein

• Target:

  SNAPIN

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, IF, WB, IHC, FC, IP

• Field of Research:

  Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  15-18 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, IF, WB, IHC, FC, IP