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SNAI1 antibody

CAT: 0710-FNab08051Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08051Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA) -induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Synonyms
Zinc finger protein SNAI1|Protein snail homolog 1 (Protein sna) |SNAI1|SNAH
Gene ID
6615
UniProt
O95863
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Snail homolog 1 (Drosophila)
Target
SNAI1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
29 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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