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SMC6 antibody

CAT: 0710-FNab08020Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08020Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541) .
Synonyms
Structural maintenance of chromosomes protein 6 (SMC protein 6, SMC-6, hSMC6) |SMC6|SMC6L1
Gene ID
79677
UniProt
Q96SB8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Structural maintenance of chromosomes 6
Target
SMC6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
130 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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