SLAMF7 antibody

CAT: 0710-FNab07903Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab07903Size:100 µg
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Background
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418) . Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536) . In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity) . May play a role in lymphocyte adhesion (PubMed:11802771) . In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528) . Isoform 3 does not mediate any NK cell activation.
Synonyms
SLAM family member 7|CD2 subset 1|CD2-like receptor-activating cytotoxic cells (CRACC) |Membrane protein FOAP-12|Novel Ly9|Protein 19A|SLAMF7|CS1
Gene ID
57823
UniProt
Q9NQ25
Host
Rabbit
Reactivity
Human
Immunogen
SLAM family member 7
Target
SLAMF7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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