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SH3BP4 antibody

CAT: 0710-FNab07830Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab07830Size:100 µg
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Background
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Synonyms
SH3 domain-binding protein 4|EH-binding protein 10|Transferrin receptor-trafficking protein|SH3BP4|BOG25|EHB10|TTP
Gene ID
23677
UniProt
Q9P0V3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SH3-domain binding protein 4
Target
SH3BP4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Field of Research
Cancer, Signal Transduction, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP
Immunogen Sequence
615-963aa

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